A world first from Mercedes-Benz, Pre-Safe is an award-winning safety system that triggers enhanced protection if an accident is deemed imminent. It is standard on all CLS-Class models as of June 2006.

Sensors fitted to the vehicle for the Brake Assist system and ESP® programme are utilised to detect potential danger, and the following measures are taken in the moments preceding an accident:
-Electric windows and the electric sunroof are closed - leaving a small gap
-Seat belts are tightened
-The front passenger seat is moved into a position that offers the best protection (only in conjunction with memory seats - optional equipment on all CLS models, standard on CLS 63 AMG)